石新军,朱旭宁,尚志远.复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究[J].声学技术,2004,(2):84~87 |
复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究 |
Cell killing of K562 cells by hematoporphyrin derivatives activated by focused bi-frequency ultrasound |
投稿时间:2003-07-14 修订日期:2003-10-24 |
DOI: |
中文关键词: 抗肿瘤效应 复频聚焦超声 血卟啉 声动力学疗法 |
英文关键词: cell-killing effect bi-frequency focused ultrasound hematoporphyrin onodynamic-therapy |
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中文摘要: |
为了研究单复频超声激活血卟啉对人体肿瘤细胞的杀伤效应,利用自制的复频聚焦换能器激活血卟啉,以肿瘤细胞K562为研究对象,采用MTT法(四唑盐比色法)检测在不同超声处理时间、不同频率、不同溶液环境下、不同孵育时间条件下,声动力学激活血卟啉法对肿瘤细胞的杀伤效应。结果表明,复频聚焦超声激活血卟啉对肿瘤细胞具有较强的杀伤效应,是一种有应用前景的治疗肿瘤的新技术。 |
英文摘要: |
A bi-frequency focusing ultrasonic transducer is used to activate hematoporphyrin in order to kill cancer cells of K(562). The cell-killing effects of the sonodynamic-therapy with different time, frequencies, liquor conditions and incubation time are studied. It is concluded that bifrequency focused ultrasound can increase the cell-killing effect in homodynamic therapy. The longer the irradiation time, the better the cell-killing effect. |
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