文章摘要
石新军,朱旭宁,尚志远.复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究[J].声学技术,2004,(2):84~87
复频聚焦超声激活血卟啉杀伤肿瘤细胞K562的实验研究
Cell killing of K562 cells by hematoporphyrin derivatives activated by focused bi-frequency ultrasound
投稿时间:2003-07-14  修订日期:2003-10-24
DOI:
中文关键词: 抗肿瘤效应  复频聚焦超声  血卟啉  声动力学疗法
英文关键词: cell-killing effect  bi-frequency focused ultrasound  hematoporphyrin  onodynamic-therapy
基金项目:
作者单位
石新军 武警广州指挥学院, 广州, 510440 
朱旭宁 武警广州指挥学院, 广州, 510440 
尚志远 陕西师范大学应用声学研究所, 西安, 710062 
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中文摘要:
      为了研究单复频超声激活血卟啉对人体肿瘤细胞的杀伤效应,利用自制的复频聚焦换能器激活血卟啉,以肿瘤细胞K562为研究对象,采用MTT法(四唑盐比色法)检测在不同超声处理时间、不同频率、不同溶液环境下、不同孵育时间条件下,声动力学激活血卟啉法对肿瘤细胞的杀伤效应。结果表明,复频聚焦超声激活血卟啉对肿瘤细胞具有较强的杀伤效应,是一种有应用前景的治疗肿瘤的新技术。
英文摘要:
      A bi-frequency focusing ultrasonic transducer is used to activate hematoporphyrin in order to kill cancer cells of K(562). The cell-killing effects of the sonodynamic-therapy with different time, frequencies, liquor conditions and incubation time are studied. It is concluded that bifrequency focused ultrasound can increase the cell-killing effect in homodynamic therapy. The longer the irradiation time, the better the cell-killing effect.
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