文章摘要
沈阳,钱德初,寿文德.声致穿孔仪的研制[J].声学技术,2004,(2):88~92
声致穿孔仪的研制
Development of sonoporation instrument
投稿时间:2003-04-04  修订日期:2003-09-04
DOI:
中文关键词: 声致穿孔  超声  换能器
英文关键词: sonoporation  ultrasound  transducer
基金项目:
作者单位
沈阳 上海交通大学生物医学工程系, 上海, 200030 
钱德初 上海交通大学生物医学工程系, 上海, 200030 
寿文德 上海交通大学生物医学工程系, 上海, 200030 
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中文摘要:
      在超声波作用下所引起的振动能改变细胞膜表面结构,可使细胞膜通透性增加。利用这一原理,近十几年来新兴起了使用超声作为辅助手段的声致穿孔方法。可以借助超声作用将目标大分子(如药物、DNA等)定点传输到细胞内,起到精确治疗和基因治疗的作用,并借助超声增强治疗效果。但其相应的实验用超声设备尚未达到完美,有多处可作改进。现有设备每次实验时只能对一个样本进行操作,作者在已有的设计思想基础上进行改进,设计制造了新的声致穿孔仪,并从导纳特性、电声效率、声功率以及声压分布等多方面对仪器的性能进行了测试。结果表明,该仪器性能达到了设计要求,使用该仪器进行的声致穿孔实验也取得了较为满意的结果。
英文摘要:
      Vibration caused by ultrasonic waves can change the structure of cell membrane and enhance its permeation. During the last decade, a new ultrasound-aided method, sonoporation, came into being. It uses ultrasound to transmit target molecules (such as drugs and DNA) into cells to perform precise therapy and gene therapy. Since current sonoporation instruments are far from perfect, much needs to be done in improving their performance. As existing instruments can only deal with one specimen, we have made improvements and developed a new type of sonoporation instrument. It has been tested with respect to its admittance, electroacoustic efficiency, transmitted sound power and distribution of sound pressure. The results show that the instrument meets the requirements, and subsequent sonoporation experiments are satisfactory.
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