文章摘要
周筠筠,谭婵媛,章东,龚秀芬.超声对鸡血与人血红细胞作用的比较研究[J].声学技术,2006,(6):602~607
超声对鸡血与人血红细胞作用的比较研究
Comparson between the effects of ultrasound on chicken and human erythrocytes
投稿时间:2006-07-01  修订日期:2006-11-12
DOI:
中文关键词: 超声  红细胞  膜透性  空化效应
英文关键词: ultrasound  erythrocytes  biomembrane permeability  cavitation
基金项目:This work is supported by Natural Science Foundation of JiangsuProvince (No. BK2004081).
作者单位
周筠筠 南京大学声学研究所近代声学重点实验室, 南京, 210093 
谭婵媛 南京大学生化系医药生物技术国家重点实验室, 南京, 210093 
章东 南京大学声学研究所近代声学重点实验室, 南京, 210093 
龚秀芬 南京大学声学研究所近代声学重点实验室, 南京, 210093 
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中文摘要:
      实验研究了1.17MHz的连续超声波作用下,人及鸡的血红细胞的溶血率、渗透脆性及膜脂过氧化水平的变化。结果表明,在声压较低时,流体间的剪切张力使得红细胞的溶血率、渗透脆性、脂质过氧化水平随作用时间及作用强度增加缓慢增长;但当声压超过空化阈值时,红细胞的溶血率随作用时间及作用强度的增加而显著增大,直至血红素完全释放细胞完全破裂;鸡红细胞的空化阈值明显高于人红细细胞,空化阈值不仅与声学参数有关,还与细胞体积和结构有关。
英文摘要:
      Under the 1.17 MHz continuous-wave ultrasound exposure, we make experimental comparisons of hemolysis, osmotic fragility and lipid peroxidation for both human erythrocyte and chicken erythrocyte dilute suspensions. Results demonstrate that ultrasound exposure at low sound intensities leads to slight increases in hemolysis, osmotic fragility and lipid peroxidation due to the effect of shear stress. However, a significant increase of hemolysis and even rupture of cell can be observed as the ultrasound intensity exceeds the cavitation threshold. The level of the cavitation threshold for chicken erythrocyte suspensions is higher than that for human red cell suspensions, suggesting that the cavitation threshold is associated with not only acoustic irradiation parameters, but also cell size and structure.
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