| 蒋文杰,孙舒心,徐峥,他得安.有限元法仿真LIPUS照射骨细胞的局部声场分布[J].声学技术,2017,36(6):549~555 |
| 有限元法仿真LIPUS照射骨细胞的局部声场分布 |
| Finite element simulation of local sound field distribution when LIPUS irradiates bone cells |
| 投稿时间：2017-06-02 修订日期：2017-08-28 |
| DOI：10.16300/j.cnki.1000-3630.2017.06.009 |
| 中文关键词: 低强度脉冲超声 有限元法 骨细胞 声场分布 仿真 |
| 英文关键词: low-intensity pulsed ultrasound Finite Element Method (FEM) bone cells sound field distribution simulation |
| 基金项目:国家自然科学基金项目（11525416） |
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| 中文摘要: |
| 低强度脉冲超声（Low-Intensity Pulsed Ultrasound，LIPUS）作为一种可用于治疗骨病的潜在物理疗法，可以有效避免药物的不良反应，且具有无创伤、无电离辐射等优点，因而有着广阔的应用前景。应用有限元法（Finite Element Method，FEM）仿真研究LIPUS照射骨细胞时的局部声场分布，从微观角度探究骨细胞与声场间的相互作用以及各超声参数和照射位置对于声场分布的影响。首先建立了骨细胞模型，然后在不同位置施加超声激励并改变超声的激励声压与频率，计算不同情况下的声场分布，最后对仿真结果进行综合分析与比较。结果表明，骨细胞会在一定程度上影响声场的分布，且超声的各个参数及照射位置均对声场有一定的影响。仿真结果从声压与能量的角度阐述了LIPUS治疗骨病的潜在物理机制，另一方面也为离体细胞实验中LIPUS的参数筛选和照射方式提供理论参考。 |
| 英文摘要: |
| Low-Intensity Pulsed Ultrasound (LIPUS), as a potential physical therapy for bone diseases, can effectively avoid the side effects of medicine and cause no traumas and ionizing radiation, which shows a wide application prospect. In this paper, Finite Element Method (FEM) is applied to simulating and studying the local sound field distribution when LIPUS irradiates bone cells, in order to explore the interaction between bone cells and sound field from a micro perspective, as well as the effects of ultrasonic parameters and irradiation positions on the sound field distribution. We first built a bone cell model, then performed ultrasound irradiation at different positions and changed the acoustic pressure and frequency to calculate the sound field distribution under different conditions, finally made a comprehensive analysis and comparison of the simulation results. The results show that bone cells will affect the sound field distribution to some extent, and both the ultrasonic parameters and the irradiation positions have a certain effect on the sound field. The simulation results explain the potential physical mechanisms in LIPUS treatment of bone cells from the aspects of acoustic pressure and energy, and on the other hand, provide a theoretical reference for the selection of LIPUS parameters and irradiation ways in in-vitro cell experiments. |
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